Triacylglycerol Synthesis by Purified Triacylglycerol Synthetase of Rat Intestinal Mucosa.
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چکیده
منابع مشابه
Intestinal triacylglycerol synthesis in fat absorption and systemic energy metabolism.
The intestine plays a prominent role in the biosynthesis of triacylglycerol (triglyceride; TAG). Digested dietary TAG is repackaged in the intestine to form the hydrophobic core of chylomicrons, which deliver metabolic fuels, essential fatty acids, and other lipid-soluble nutrients to the peripheral tissues. By controlling the flux of dietary fat into the circulation, intestinal TAG synthesis c...
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Rat hepatocytes were treated with Staphylococcus aureus alpha-toxin to permeabilize their plasma membrane for low-molecular-mass compounds. During incubation with 1 mM labelled fatty acid, phosphatidate and, less clearly, lysophosphatidate rapidly reached a steady state, whereas labelled diacylglycerol accumulated to some extent, at least in the absence of exogenous CDP-choline. Esterification ...
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The excessive synthesis and storage of triacylglycerol (triglyceride) has a number of clinical implications. It is obviously the main symptom of obesity where excess lipid is stored in adipose tissue. Abnormal accumulations of triacylglycerols can also be manifested as a fatty liver, e.g. as a'result of the ingestion or inhalation of toxic compounds and damage to the liver. These conditions are...
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Studies showing a correlation of excess myocardial triacylglycerol stores with apoptosis, fibrosis, and contractile dysfunction indicate that dysregulation of triacylglycerol metabolism may contribute to cardiac disease. This review covers the regulation of heart triacylglycerol accumulation at the critical control points of fatty acid uptake, enzymes of triacylglycerol synthesis, lipolysis, an...
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Since the pathways of glycerolipid biosynthesis were elucidated in the 1950's, considerable knowledge has been gained about the enzymes that catalyze the lipid biosynthetic reactions and the factors that regulate triacylglycerol biosynthesis. In the last few decades, in part due to advances in technology and the wide availability of nucleotide and amino acid sequences, we have made enormous str...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1995
ISSN: 0021-9258
DOI: 10.1074/jbc.270.23.13630